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Keep an eye on Closely (1)pentobarbital will minimize the level or result of osilodrostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the level or influence of ramelteon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Not known.Contraindicated (1)pentobarbital decreases levels

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